COMPOSITION
| Paracetamol |
500 mg |
| Chlorpheniramine Maleate |
2 mg |
| Phenylephrine HCL |
5 mg |
| Caffeine |
30 mg |
ANTIHISTAMINES, DECONGESTANTS, MOOD ELEVATOR AND ANALGESICS (SYSTEMIC} DESCRIPTION
Antihistamine, decongestant, and analgesic combination are taken by mouth to relieve the sneezing, runny nose, nasal congestion ( stuffy nose), fever, headache and aches.
Chlorphenirarmne Maleate - Antihistamine blocks HI receptor thus controls allergic manifestation
phenylephrine HCL - Nasal decongestant. It is selective alpha adreno receptor agonist, Thus constricts the blood vessel which leads to clearing of nasal passage.
|
PARAMETER
|
PPA
|
PSUEDOEPHEDRINE
|
PHENYLEPHRINE
|
|
Adrenergic Alpha-1 Receptor Selectivity
|
Nonselective
|
Nonselective
|
Selective
|
|
Bleed Pressure
|
Increase
|
Increase
|
Less chance
|
|
CNS Side Effects 1 Nervousness, Anxiety, Loss of Appetite Insomnia)
|
Yes
|
Yes
|
Less
|
|
Urinary bladder obstruction
|
Yes
|
Yes
|
No
|
|
Rebound hyperemia
|
High
|
High
|
No
|
|
US FDA
|
Banned
|
Warned
|
Approved
|
|
Drug Addiction
|
Low
|
High
|
No
|
|
Reported
adverse effect
|
Intracerebral hemorrhage
|
Drug addiction
|
No
|
US FDA WARNING AGAINST PPA
The Food and Drug Administration (FDA) is taking steps to remove phenylpropanolamine (PPA) from all drugs and has requested that all drug companies discontinue marketing products containing PPA
REASON
phenylpropanolamine and risk of Hemorrhagic Stroke: Final Report of the Hemorrhagic Stroke Project. It can also aggravate diabetes, glaucoma and Prostate enlargement
SIDE EFFECTS OF PSEUDOEPHEDRINE
- Stimulation of the nervous system leading to nervousness, restlessness and excitability.
- Dizziness, headache, fear, anxiety, tremor.
- Hallucinations and convulsion (Seizure)
CAFFEINE - EFFECTS OF CAFFEINE ON THE NERVOUS SYSTEM
Caffeine is a central nervous system stimulant and belongs to the methylxanthine derivative. In moderate doses, caffeine can increase alertness.Caffeine enters the bloodstream through the stomach and small intestine and can have its effects within 15 minutes after it is
consumed,
